Potent Antimycobacterial Activity of Mouse Secretory Leukocyte Protease Inhibitor

Secretory Leukocyte Protease Inhibitor Potent Antimycobacterial Activity of Mouse

Immunoregulatory role of secretory leukocyte protease inhibitor in allergic asthma

Background Asthma is a complex and multi-factorial inflammatory disease [1]. It is one of the most common chronic diseases among children and adolescents [2]. Secretory leukocyte protease inhibitor (SLPI) has shown higher levels in asthmatic patients and its function as an anti-inflammatory protein has been documented in respiratory diseases [3,4]. However, its role in the immunomodulation of t...

Secretory leukocyte protease inhibitor as an indicator of periodontal disease

Secretory Leukocyte Protease Inhibitor: A Human Saliva Protein Exhibiting

Infection of adherent primary monocytes with HIV-lBa.L is significantly suppressed in the presence of human saliva. By reverse transcriptase (RT) levels, saliva, although present for only 1 h during monocyte viral exposure, inhibited HIV1 infectivity for 3 wk after infection, whereas human plasma and synovial fluid failed to inhibit HIV-1 infectivity. Antiviral activity was identified in the sa...

Secretory leukocyte protease inhibitor antagonizes paclitaxel in ovarian cancer cells.

PURPOSE Ovarian cancer recurrence with the development of paclitaxel resistance is an obstacle to long-term survival. We showed that secretory leukocyte protease inhibitor (SLPI) is a survival factor for ovarian cancer. We hypothesize that SLPI may antagonize paclitaxel injury. EXPERIMENTAL DESIGN Differential SLPI induction in response to paclitaxel and in response to stable forced expressio...